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Article

Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated.

The Journal of biological chemistry - 30 Sept 1994

Pedone P V, Cosma M P, Ungaro P, Colantuoni V, Bruni C B, Zarrilli R, Riccio A

Abstract excerpt

The insulin-like growth factor II (IGF-II) gene is parentally imprinted in the mouse and human species. By following the inheritance of natural polymorphisms of IGF-II mRNA, we demonstrated that the tissue-specific parental imprinting of the IGF-II gene is conserved in the rat. The expression of the paternal IGF-II allele exceeded by more than 3 orders of magnitude that of the maternal allele in livers of...

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PMID: 7929045

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