Article
CYP2D6-related oxidation polymorphism in Italy.
Pharmacological research - 1 Apr 1994
Spina E, Campo G M, Avenoso A, Caputi A P, Zuccaro P, Pacifici R, Gatti G, Strada G, Bartoli A, Perucca E
Abstract excerpt
The distribution of the oxidation polymorphism related to cytochrome CYP2D6 (debrisoquine type) was determined in 246 healthy Italian volunteers. Phenotyping was based on HPLC determination of the dextrometorphan/dextrorphan concentration ratio (metabolic ratio) in urine samples collected over an...
Topics
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Dextrorphan
- Female
- Humans
- Italy
- Liver
- Male
- Mixed Function Oxygenases
- Phenotype
- Polymorphism, Genetic
- Racial Groups