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Article

CYP2D6-related oxidation polymorphism in Italy.

Pharmacological research - 1 Apr 1994

Spina E, Campo G M, Avenoso A, Caputi A P, Zuccaro P, Pacifici R, Gatti G, Strada G, Bartoli A, Perucca E

Abstract excerpt

The distribution of the oxidation polymorphism related to cytochrome CYP2D6 (debrisoquine type) was determined in 246 healthy Italian volunteers. Phenotyping was based on HPLC determination of the dextrometorphan/dextrorphan concentration ratio (metabolic ratio) in urine samples collected over an 8 h interval following a single oral 30 mg dose of dextromethorphan hydrobromide. Urinary excretion of...

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Identifiers

PMID: 8058599
DOI: 10.1016/1043-6618(94)80051-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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