Prediction of phenotype for dextromethorphan O-demethylation by using polymerase chain reaction in healthy volunteers.

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Article

Prediction of phenotype for dextromethorphan O-demethylation by using polymerase chain reaction in healthy volunteers.

Arzneimittel-Forschung - 1 Jan 1995

Zimmermann T, Schlenk R, Pfaff G, Lach P, Wildfeuer A

Abstract excerpt

The polymorphism of dextromethorphan (CAS 125-71-3) metabolism is dependent on hepatic cytochrom P4502D6 (CYP2D6) activity. The relationship between the CYP2D6 genotype and the dextromethorphan phenotype was studied in 83 healthy unrelated subjects. Genotype was determined by allele-specific poly...

Topics

Adult
Alleles
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
DNA
Dealkylation
Dextromethorphan
Dextrorphan
Female
Genotype
Humans
Leukocytes
Male
Mixed Function Oxygenases
Mutation
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7893267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7893267-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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