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Article

Development of an ELISA to study the polymorphism of dextromethorphan oxidation in a French population.

European journal of clinical pharmacology - 1 Jan 1990

Frèche J P, Dragacci S, Petit A M, Siest J P, Galteau M M, Siest G

Abstract excerpt

Simple, sensitive and selective enzyme immunoassays (ELISA) for monitoring urinary dextromethorphan and its major metabolite, dextrorphan, were developed. Dextromethorphan and dextrorphan hemisuccinates were linked to bovine serum albumin and specific antisera against each immunogen were raised in rabbits. The sensitivity of the ELISA was high (limit of detection 740 and 600 pg.ml-1 for dextromethorphan and...

Topics

Chromatography, High Pressure Liquid
Dextromethorphan
Enzyme-Linked Immunosorbent Assay
Female
France
Humans
Male
Oxidation-Reduction
Phenotype
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2076741
DOI: 10.1007/BF00280940

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2076741-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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