Article
Low-level c-myc amplification in human colonic carcinoma cell lines and tumors: a frequent, p53-independent mutation associated with improved outcome in a randomized multi-institutional trial.
Cancer research - 1 May 1997
Augenlicht L H, Wadler S, Corner G, Richards C, Ryan L, Multani A S, Pathak S, Benson A, Haller D, Heerdt B G
Abstract excerpt
Human colonic cancer is associated with multiple genetic deletions, mutations, and alterations in gene expression; in contrast, gene amplification has not been recognized as a prominent characteristic of human colonic tumors. Although the c-myc gene is overexpressed in approximately 70% of human colonic cancers, previous studies have not detected frequent gene amplification or rearrangement of c-myc in these...
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