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Article

Presence of Twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors.

Gastroenterology - 1 Sept 2013

Celesti Giuseppe, Di Caro Giuseppe, Bianchi Paolo, Grizzi Fabio, Basso Gianluca, Marchesi Federica, Doni Andrea, Marra Giancarlo, Roncalli Massimo, Mantovani Alberto, Malesci Alberto, Laghi Luigi

Abstract excerpt

BACKGROUND & AIMS: Cancer cells undergo an epithelial-to-mesenchymal transition (EMT) to become invasive, allowing tumors to progress. However, there is no direct evidence that human cancer cells undergo an EMT. In mouse cancer cells, up-regulation of transcription factor Twist1 was shown to promote an EMT. We searched the stroma of human colorectal tumor samples for TWIST1-positive cells with a mesenchymal...

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Source

Identifiers

PMID: 23684708
DOI: 10.1053/j.gastro.2013.05.011

Genes

TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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