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Article

Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastases.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Dec 1995

Rochlitz C F, Heide I, Thiede C, Herrmann R, de Kant E

Abstract excerpt

BACKGROUND: Alterations of the c-myc and the p53 genes occur in a majority of human colorectal cancers, and functional interaction between these two genes has recently been suggested. PATIENTS AND METHODS: We analyzed p53 sequence and c-myc and p53 mRNA expression in 26 metastases and 4 advanced primaries of human colorectal cancer. RESULTS: Twenty-one of 30 tumors (=70%) carried mutations of the p53 gene. In...

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Source

Identifiers

PMID: 8750149
DOI: 10.1093/oxfordjournals.annonc.a059094

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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