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Article

Primary tumour genetic alterations and intra‐tumoral heterogeneity are maintained in xenografts of human colon cancers showing chromosome instability

31 Jan 2006

Abstract excerpt

Evaluation of the role of clonal heterogeneity in colon tumour sensitivity/resistance to drugs and/or in conferring metastatic potential requires an adequate experimental model in which the tumour cells maintain the initial genetic alterations and intra-tumoral heterogeneity through maintenance of the genetic clones present in the initial tumour. Therefore, we xenografted subcutaneously into nude mice seven human...

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PMID: 16450341
DOI: 10.1002/path.1936

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