Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene.

doi:10.1038/sj.onc.1202309

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Article

Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene.

Oncogene - 14 Jan 1999

Donzelli M, Bernardi R, Negri C, Prosperi E, Padovan L, Lavialle C, Brison O, Scovassi A I

Abstract excerpt

Although apoptosis can be induced by the enforced expression of exogenously introduced c-myc genes, it is not clear whether overexpression resulting from the amplification of the resident c-myc gene in tumor cells is sufficient to induce apoptosis. We have investigated the relationship between c-...

Topics

Clone Cells
Colonic Neoplasms
Culture Media, Serum-Free
Gene Expression Regulation, Neoplastic
Genes, myc
Genes, p53
Humans
Phenotype
Transfection
Tumor Cells, Cultured

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