Article
Apoptosis-prone phenotype of human colon carcinoma cells with a high level amplification of the c-myc gene.
Oncogene - 14 Jan 1999
Donzelli M, Bernardi R, Negri C, Prosperi E, Padovan L, Lavialle C, Brison O, Scovassi A I
Abstract excerpt
Although apoptosis can be induced by the enforced expression of exogenously introduced c-myc genes, it is not clear whether overexpression resulting from the amplification of the resident c-myc gene in tumor cells is sufficient to induce apoptosis. We have investigated the relationship between c-myc gene amplification and the propensity of tumor cells to undergo apoptosis, using the SW613-12A1 and SW613-B3 cell...
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