c-myc Amplification Is Frequent in Esophageal Adenocarcinoma and Correlated with the Upregulation of VEGF-A Expression

Abstract excerpt

BACKGROUND: Deregulation of c-myc plays a major role in the carcinogenesis of human malignancies. We investigated the amplification of the c-myc gene in a surgical series of Barrett cancers. METHODS: Primary resected esophageal (Barrett) adenocarcinomas (n = 84) were investigated for c-myc amplification using chromogene in situ hybridization. Tumor samples were assembled in a tissue microarray. c-myc gene dosage...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Esophageal Cancer Research and Treatment
• Share to Inflammatory mediators and NSAID effects
• Share to Microbial metabolism and enzyme function