Article
p53 alterations are associated with improved prognosis in distal colonic carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1997
Soong R, Grieu F, Robbins P, Dix B, Chen D, Parsons R, House A, Iacopetta B
Abstract excerpt
Alterations of the p53 gene and the p53 protein are common in a wide spectrum of human malignancies. In several tumor types, p53 gene mutation and/or p53 protein overexpression correlate with a more clinically aggressive phenotype as judged by worse patient survival. This has not been clearly dem...
Topics
- Aged
- Colonic Neoplasms
- Colorectal Neoplasms
- Confidence Intervals
- Exons
- Female
- Follow-Up Studies
- Genes, p53
- Humans
- Male
- Mutation
- Neoplasm Staging
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Proportional Hazards Models
- Survival Analysis
- Time Factors