Article
p53 alterations are associated with improved prognosis in distal colonic carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 1997
Soong R, Grieu F, Robbins P, Dix B, Chen D, Parsons R, House A, Iacopetta B
Abstract excerpt
Alterations of the p53 gene and the p53 protein are common in a wide spectrum of human malignancies. In several tumor types, p53 gene mutation and/or p53 protein overexpression correlate with a more clinically aggressive phenotype as judged by worse patient survival. This has not been clearly demonstrated to be the case in colorectal cancer. Herein, we report results of the prognostic significance of p53 protein...
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