Article
Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans.
Journal of pharmacokinetics and biopharmaceutics - 1 Oct 1996
Wilkinson G R
Abstract excerpt
CYP3A is one of the most important cytochrome P450 isoforms responsible for drug metabolism by humans because it is the major such enzyme in critical tissues such as the gastrointestinal tract and liver, and it is involved in the oxidative biotransformation of numerous clinically useful therapeut...
Topics
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Cyclosporine
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Drug Design
- Drug Interactions
- Enzyme Induction
- Female
- Genetic Variation
- Histamine H1 Antagonists
- Humans
- Immunosuppressive Agents
- Intestinal Mucosa
- Liver
- Male
- Oxidoreductases, N-Demethylating
- Pharmaceutical Preparations