Article
Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.
Annual review of pharmacology and toxicology - 1 Jan 2004
Miners John O, Smith Paul A, Sorich Michael J, McKinnon Ross A, Mackenzie Peter I
Abstract excerpt
Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT), which both exist as enzyme "superfamilies," are together responsible for the metabolism of most hepatically cleared drugs. There is currently intense interest in the development of techniques that permit identification of the CYP and UGT isoform(s) involved in the metabolism of a newly discovered drug, and hence prediction of factors likely to alter...
Topics
- Cytochrome P-450 Enzyme System
- Glucuronides
- Glucuronosyltransferase
- Humans
- In Vitro Techniques
- Microsomes, Liver
- Models, Biological
- Models, Molecular
- Pharmacokinetics
- Phenotype