Cytochrome P450 reaction phenotyping: State of the art.

doi:10.1016/j.dmpk.2025.101508

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Cytochrome P450 reaction phenotyping: State of the art.

Drug metabolism and pharmacokinetics - 1 Feb 2026

Tseng Elaine, Obach R Scott

Abstract excerpt

Cytochrome P450 reaction phenotyping refers to the in vitro experimental approach that estimates the quantitative contributions of individual P450 enzymes to the metabolism of a drug. Methods for this are well-established and have existed for over three decades and include the use of selective inhibitors, individually expressed P450 enzymes, and human-derived in vitro systems such as liver microsomes and...

Topics

Humans
Cytochrome P-450 Enzyme System
Phenotype
Cytochrome P-450 Enzyme Inhibitors
Microsomes, Liver
Pharmaceutical Preparations
Animals

Source

Open in PubMed

Identifiers

PMID: 41494466
DOI: 10.1016/j.dmpk.2025.101508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics