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Article

CYP3A activity: towards dose adaptation to the individual.

Expert opinion on drug metabolism & toxicology - 1 May 2016

Hohmann Nicolas, Haefeli Walter E, Mikus Gerd

Abstract excerpt

INTRODUCTION: Co-medication, gene polymorphisms and co-morbidity are main causes for high variability in expression and function of the CYP3A isoenzymes. Pharmacokinetic variability is a major source of interindividual variability of drug effect and response of CYP3A substrates. While CYP3A genotyping is of limited use, direct testing of enzyme function ('phenotyping') may be more promising to achieve...

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Identifiers

PMID: 26950050
DOI: 10.1517/17425255.2016.1163337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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