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Article

Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences.

Current drug metabolism - 1 Jun 2002

Rodrigues A David, Rushmore Thomas H

Abstract excerpt

Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been shown to be polymorphic as a result of single nucleotide polymorphisms (SNPs), gene deletions, and gene duplications. These polymorphisms can impact the pharmacokinetics (PK), metabolism, safety and efficacy of drugs, and because of the availability of...

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Identifiers

PMID: 12083322
DOI: 10.2174/1389200023337522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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