Article
In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
Current opinion in drug discovery & development - 1 Jan 2005
Williams J Andrew, Bauman Jonathan, Cai Hongliang, Conlon Kevin, Hansel Steven, Hurst Susan, Sadagopan Nalini, Tugnait Meera, Zhang Liming, Sahi Jasminder
Abstract excerpt
Drug-metabolizing enzymes and drug transporters are key regulators of drug disposition and pharmacodynamics, which are closely linked to drug efficacy and safety. In this article, current challenges and future solutions to predicting their influence on pharmacokinetics and inter-organ distribution in humans, from data generated during the drug discovery decision-making process, are presented. In vitro phenotyping...
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