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Article

Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models

1 Nov 2001

Abstract excerpt

The cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are responsible for the biotransformation of numerous xenobiotics, including therapeutic agents. Studies of the biochemical and enzymatic properties of these enzymes and their molecular genetics and regulation of gene expression and activity have greatly enhanced our understanding of several aspects of clinical pharmacology such as...

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PMID: 11697750
DOI: 10.1177/00912700122012724

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