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Article

Drugs as CYP3A Probes, Inducers, and Inhibitors

1 Jan 2007

Abstract excerpt

Human cytochrome P450 (CYP) 3A subfamily members (mainly CYP3A4 and CYP3A5) mediate the metabolism of approximately half all marketed drugs and thus play a critical role in the drug metabolism. A huge number of studies on CYP3A-mediated drug metabolism in humans have demonstrated that CYP3A activity exhibits marked ethnic and individual variability, in part because of altered levels of CYP3A4 expression by...

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PMID: 18058330
DOI: 10.1080/03602530701690374

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