Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2007

Lu Chuang, Miwa Gerald T, Prakash Shimoga R, Gan Liang-Shang, Balani Suresh K

Abstract excerpt

Ketoconazole has generally been used as a standard inhibitor for studying clinical pharmacokinetic drug-drug interactions (DDIs) of drugs that are primarily metabolized by CYP3A4/5. However, ketoconazole at therapeutic, high concentrations also inhibits cytochromes P450 (P450) other than CYP3A4/5, which has made the predictions of DDIs less accurate. Determining the in vivo inhibitor concentration at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 Enzyme Inhibitors
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Interactions

Share to Enzyme Inhibitors

Share to Hepatocytes

Share to Models, Biological

Share to Phenotype

Share to Plasma

Source

Identifiers

PMID: 17020957
DOI: 10.1124/dmd.106.011346

Genes

MLX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data.PMID 17020957Read ↗

Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole.Semantic proximity Read ↗

In vitro identification of cytochrome P450 enzymes responsible for drug metabolism.Semantic proximity Read ↗

Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro ModelsSemantic proximity Read ↗

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans.Semantic proximity Read ↗

Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its MechanismSemantic proximity Read ↗

In Vitro Reaction Phenotyping and Projection of Drug Interactions Mediated by Cytochrome P450 Enzymes for Central Nervous System Drugs as Victims: Implications for Safety in Vulnerable Populations.Semantic proximity Read ↗

Cytochrome P450 reaction phenotyping: State of the art.Semantic proximity Read ↗

A comparison of relative abundance, activity factor and inhibitory monoclonal antibody approaches in the characterization of human CYP enzymology.Semantic proximity Read ↗

Effect of CYP3A5 expression on the inhibition of CYP3A-catalyzed drug metabolism: impact on modeling CYP3A-mediated drug-drug interactions.Semantic proximity Read ↗

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo.Semantic proximity Read ↗

A High-Throughput (HTS) Assay for Enzyme Reaction Phenotyping in Human Recombinant P450 Enzymes Using LC-MS/MS.Semantic proximity Read ↗

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.