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Article

Human drug-metabolizing enzyme polymorphisms: effects on risk of toxicity and cancer.

DNA and cell biology - 1 Apr 1996

Nebert D W, McKinnon R A, Puga A

Abstract excerpt

A growing number of human genetic polymorphisms in drug-metabolizing enzymes (DMEs) are being characterized. Some of these have been shown, quite convincingly, to be correlated with risk of toxicity or cancer, whereas others presently remain equivocal. There is good evidence that the correlation is stronger in populations exposed to a variety of environmental procarcinogens; perhaps 30% of DME substrates are able...

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Source

Identifiers

PMID: 8639263
DOI: 10.1089/dna.1996.15.273

Genes

AHR
GSTM1
NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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