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Article

Genetic polymorphisms of drug metabolism.

Fundamental & clinical pharmacology - 1 Jan 1990

Meyer U A

Abstract excerpt

The molecular mechanisms of 3 genetic polymorphisms of drug metabolism have been studied at the level of enzyme activity, enzyme protein and RNA/DNA. As regards debrisoquine/sparteine polymorphism, cytochrome P-450IID6 was absent in livers of poor metabolizers; aberrant splicing of premRNA of P-450IID6 may be responsible for this. Moreover, 3 mutant alleles of the P-450IID6 locus on chromosome 22 associated with...

Topics

Acetylation
Arylamine N-Acetyltransferase
Cytochrome P-450 Enzyme System
Humans
Hydroxylation
Liver
Oxidation-Reduction
Pharmaceutical Preparations
Phenotype
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1982880
DOI: 10.1111/j.1472-8206.1990.tb00041.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1982880-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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