Article
Polymorphism in the 5' terminal region of the mRNA of HLA-DQA1 gene: identification of four groups of transcripts and their association with polymorphism in the alpha 1 domain.
Human immunology - 1 Apr 1997
Maffei A, Pozzo G D, Prisco A, Ciullo M, Harris P E, Reed E F, Guardiola J
Abstract excerpt
Relative to other loci in the MHC, the HLA-DQ locus exhibits an exceptional degree of polymorphism of both A1 and B1 genes, particularly in the region coding for alpha and beta chains. Diversification of the association between different alpha and beta molecules either in cis or in trans contributes to the structural diversity of the repertoire of cell-surface class II protein's in the population. In addition,...
Topics
- B-Lymphocytes
- Base Sequence
- Cell Line, Transformed
- Chromosome Mapping
- Genetic Linkage
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Humans
- Nucleic Acid Conformation
- Polymorphism, Genetic
- RNA, Messenger
- Transcription, Genetic