Article
A new splicing acceptor site and poly(A)+ sequence signal within DQA1*0401 and DQA1*0501 mRNA 3'UTR contribute to increase the extraordinary diversity of mRNA isoforms.
Immunogenetics - 1 May 2005
Hoarau J J, Festy F, Cesari M, Pabion M
Abstract excerpt
In this paper, we have analysed the diversity of mRNA species generated by DQA1*0501 and DQA1*0401 alleles in homozygous B-lymphoblastoid cell lines. As we previously reported, six mRNA isoforms that differ in the 3'UTR have been identified in these cells. This diversity of mRNA species results both from the alternative use of two acceptor spliced sites and the differential selection of two poly(A)+ sequence...
Topics
- 3' Untranslated Regions
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Cell Line
- DNA, Complementary
- Genetic Variation
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Humans
- Molecular Sequence Data
- RNA Splicing
- RNA, Messenger
- Sequence Homology, Nucleic Acid
- Signal Transduction