Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes.

The Journal of experimental medicine - 1 Jan 1991

Andersen L C, Beaty J S, Nettles J W, Seyfried C E, Nepom G T, Nepoom B S

Abstract excerpt

Class II genes of the human major histocompatibility complex (MHC) are highly polymorphic. Allelic variation of structural genes provides diversity in immune cell interactions, contributing to the formation of the T cell repertoire and to susceptibility to certain autoimmune diseases. We now report that allelic polymorphism also exists in the promoter and upstream regulatory regions (URR) of human...

Topics

Alleles
B-Lymphocytes
Base Sequence
Cell Line
Chloramphenicol O-Acetyltransferase
Consensus Sequence
DNA-Binding Proteins
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Promoter Regions, Genetic

Regulatory Sequences, Nucleic Acid

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1985121
DOI: 10.1084/jem.173.1.181
PMCID: PMC2118753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1985121-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes.PMID 1985121Read ↗

Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.Semantic proximity Read ↗

Qualitative and quantitative analysis of HLA-DRB gene expression.Semantic proximity Read ↗

Allelic polymorphism in the upstream regulatory region of HLA-DRB genes: functional role of conserved consensus motifs.Semantic proximity Read ↗

Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box.Semantic proximity Read ↗

Comparative analysis of sequence variability in the upstream regulatory region of the HLA-DQB1 gene.Semantic proximity Read ↗

Sequence variations in the transcriptional regulatory region and intron1 of HLA-DQB1 gene and their linkage in southern Chinese ethnic groups.Semantic proximity Read ↗

Allelic variation in transcription modulates MHC class II expression and function.Semantic proximity Read ↗

The regulatory complex of HLA class I promoters exhibits locus-specific conservation with limited allelic variation.Semantic proximity Read ↗

Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes.Semantic proximity Read ↗

Polymorphism in the regulatory regions of the HLA-DPB1 gene.Semantic proximity Read ↗

Single nucleotide polymorphisms in the regulatory regions of the HLA-DRB-expressed genes.Semantic proximity Read ↗

Sequence polymorphism in the HLA-B promoter region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.