Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.

doi:10.1128/MCB.15.9.4771

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Article

Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1.

Molecular and cellular biology - 1 Sept 1995

Beaty J S, West K A, Nepom G T

Abstract excerpt

DNA sequence polymorphism in the genes encoding HLA class II proteins accounts for allelic diversity in antigen recognition and presentation and, thus, in the role of these cell surface glycoproteins as determinants of the scope of the T-cell repertoire. In addition, sequence polymorphism in the promoter-proximal transcriptional regulatory regions of these genes has been described, particularly for the HLA-DQB1...

Topics

Alleles
B-Lymphocytes
Base Sequence
Cells, Cultured
Chloramphenicol O-Acetyltransferase
Fibroblasts
Gene Expression Regulation
Genes, Reporter
HLA-DQ Antigens
HLA-DQ beta-Chains
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interferon-gamma

Molecular Sequence Data

Nuclear Proteins

Polymerase Chain Reaction

Polymorphism, Genetic

Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 7651394
DOI: 10.1128/MCB.15.9.4771
PMCID: PMC230721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7651394-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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