Article
Sequence and Phylogenetic Analysis of the Untranslated Promoter Regions for HLA Class I Genes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2017
Ramsuran Veron, Hernández-Sanchez Pedro G, O'hUigin Colm, Sharma Gaurav, Spence Niamh, Augusto Danillo G, Gao Xiaojiang, García-Sepúlveda Christian A, Kaur Gurvinder, Mehra Narinder K, Carrington Mary
Abstract excerpt
Polymorphisms located within the MHC have been linked to many disease outcomes by mechanisms not yet fully understood in most cases. Variants located within untranslated regions of HLA genes are involved in allele-specific expression and may therefore underlie some of these disease associations. We determined sequences extending nearly 2 kb upstream of the transcription start site for 68 alleles from 57 major...
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