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Article

Differences in promoter DNA methylation and mRNA expression of individual alleles of the HLA class II DQA1 gene.

Immunology letters - 1 Oct 2015

Zajacova Marta, Kotrbova-Kozak Anna, Cepek Pavel, Cerna Marie

Abstract excerpt

OBJECTIVES: Extensive polymorphism of HLA class II genes is not restricted to the coding region of the gene. It extends also to the linked promoter region, where it forms the basis for different levels of individual allele's expression. Differential expression of HLA class II alleles can shape an immune response and influence the risk of developing autoimmune disease. In addition to genetic variability, variation...

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Identifiers

PMID: 26297837
DOI: 10.1016/j.imlet.2015.08.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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