Article
Locus- and allele-specific DNA-protein interactions in the HLA-DQB1 X box.
Immunologic research - 1 Jan 1993
Sukiennicki T L, Shewey L M, Nepom G T
Abstract excerpt
Expression of MHC class II genes is regulated by a complex series of protein-DNA interactions which lead to the initiation of transcription. Although the different MHC class II loci are generally coordinately expressed, important differences in expression can be seen among loci and among individual alleles. The major sites of transcriptional control in the human MHC consist of several highly conserved nucleotide...
Topics
- Alleles
- Base Sequence
- Cell Line, Transformed
- Chromosome Mapping
- DNA-Binding Proteins
- Gene Expression Regulation
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Humans
- Molecular Sequence Data
- Promoter Regions, Genetic