Article
Does cytochrome 2D6 genotype affect the analgesic efficacy of codeine after ambulatory surgery? Prospective trial in 987 adults.
Acta anaesthesiologica Scandinavica - 1 Jan 2025
Poikola Satu, von Plato Hanna, Harju Jukka, Kiiski Johanna I, Mattila Kristiina, Olkkola Klaus T, Niemi Mikko, Kalso Eija, Kontinen Vesa
Abstract excerpt
BACKGROUND: Paracetamol-codeine combination tablet is widely used in pain management after day surgery. For safety reasons, its use has decreased in recent years. Codeine is a prodrug metabolised in the liver by the cytochrome P450 2D6 (CYP2D6) enzyme to morphine that produces the analgesic effect of codeine. CYP2D6 is highly polymorphic, and based on genotypes, individuals can be divided into four categories:...
Topics
- Humans
- Codeine
- Cytochrome P-450 CYP2D6
- Male
- Female
- Ambulatory Surgical Procedures
- Middle Aged
- Prospective Studies
- Genotype
- Adult
- Postoperative Pain
- Analgesics, Opioid
- Acetaminophen
- Aged