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Article

Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.

European journal of immunology - 1 Apr 1990

Reininger L, Shibata T, Ozaki S, Shirai T, Jaton J C, Izui S

Abstract excerpt

New Zealand Black (NZB) mice spontaneously develop a severe autoimmune hemolytic anemia due to the production of anti-mouse red blood cell (MRBC) autoantibodies. The contribution of variable region genes and somatic mutations in the pathogenicity of anti-MRBC autoantibodies was investigated by mR...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Autoantibodies
Autoimmune Diseases
Base Sequence
Erythrocytes
Genes, Immunoglobulin
Mice
Mice, Inbred BALB C
Mice, Inbred NZB
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Source

Identifiers

PMID: 2347362
DOI: 10.1002/eji.1830200410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2347362-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Variable region sequences of pathogenic anti-mouse red blood cell autoantibodies from autoimmune NZB mice.PMID 2347362Read ↗

Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody family.Semantic proximity Read ↗

Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily.Semantic proximity Read ↗

Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Semantic proximity Read ↗

Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody.Semantic proximity Read ↗

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Two induced anti-Z-DNA monoclonal antibodies use VH gene segments related to those of anti-DNA autoantibodiesSemantic proximity Read ↗

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