Article
Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005
Woodward Emily J, Thomas James W
Abstract excerpt
The highly selective nature of organ-specific autoimmune disease is consistent with a critical role for adaptive immune responses against specific autoantigens. In type 1 diabetes mellitus, autoantibodies to insulin are important markers of the disease process in humans and nonobese diabetic (NOD) mice; however, the Ag-specific receptors responsible for these autoantibodies are obscured by the polyclonal...
Topics
- Animals
- Antibody Diversity
- Autoantibodies
- B-Lymphocyte Subsets
- Base Sequence
- Bone Marrow Cells
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genetic Predisposition to Disease
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Insulin
- Insulin Antibodies
- Mice
- Mice, Inbred BALB C