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Article

Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2005

Woodward Emily J, Thomas James W

Abstract excerpt

The highly selective nature of organ-specific autoimmune disease is consistent with a critical role for adaptive immune responses against specific autoantigens. In type 1 diabetes mellitus, autoantibodies to insulin are important markers of the disease process in humans and nonobese diabetic (NOD) mice; however, the Ag-specific receptors responsible for these autoantibodies are obscured by the polyclonal...

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Share to Antibody Diversity
Share to B-Lymphocyte Subsets
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16002708
DOI: 10.4049/jimmunol.175.2.1073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple germline kappa light chains generate anti-insulin B cells in nonobese diabetic mice.PMID 16002708Read ↗

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