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Article

Evaluation of a potential regulatory role for inverted CCAAT boxes in the human topoisomerase II alpha promoter.

Biochemical and biophysical research communications - 27 Mar 1997

Herzog C E, Zwelling L A

Abstract excerpt

Several chemotherapeutic agents act via inhibition of topoisomerase (topo) II activity. Topo II levels appear to correlate with drug sensitivity in vivo. The DNA immediately 5' to the topo II alpha coding region contains five potentially regulatory inverted CCAAT boxes (ICB). Electrophoretic mobility shift assays (EMSA) using oligomers containing the wild type forms of these ICBs show specific DNA-protein...

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Identifiers

PMID: 9126321
DOI: 10.1006/bbrc.1997.6267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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