Article
Evaluation of a potential regulatory role for inverted CCAAT boxes in the human topoisomerase II alpha promoter.
Biochemical and biophysical research communications - 27 Mar 1997
Herzog C E, Zwelling L A
Abstract excerpt
Several chemotherapeutic agents act via inhibition of topoisomerase (topo) II activity. Topo II levels appear to correlate with drug sensitivity in vivo. The DNA immediately 5' to the topo II alpha coding region contains five potentially regulatory inverted CCAAT boxes (ICB). Electrophoretic mobi...
Topics
- Antigens, Neoplasm
- Base Sequence
- Binding Sites
- Binding, Competitive
- DNA
- DNA Topoisomerases, Type II
- DNA-Binding Proteins
- Electrophoresis, Polyacrylamide Gel
- HL-60 Cells
- Humans
- Isoenzymes
- Mutation
- Promoter Regions, Genetic
- Protein Binding