Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

15 Apr 1993

Abstract excerpt

Many cytotoxic anticancer drugs act at topoisomerase II (topo II) by stabilizing cleavable complexes with DNA formed by this enzyme. Several cell lines, selected for resistance to topo II-interactive drugs, show decreased expression or activity of topo II, suggesting that such a decrease may be responsible for drug resistance. In the present study, etoposide resistance was used as the selection strategy to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to DNA and Nucleic Acid Chemistry
Share to Lung Cancer Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8386368
DOI: 10.1073/pnas.90.8.3231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.PMID 8386368Read ↗

DNA topoisomerase II mutations and resistance to anti-tumor drugs.Semantic proximity Read ↗

[Incidence of mutation and deletion in topoisomerase II mRNA of etoposide and m-AMSA resistant cell lines].Semantic proximity Read ↗

Etoposide, Topoisomerase II and CancerSemantic proximity Read ↗

Use of CRISPR/Cas9 with Homology-Directed Repair to Gene-Edit Topoisomerase IIβ in Human Leukemia K562 Cells: Generation of a Resistance Phenotype.Semantic proximity Read ↗

Differential Targeting of Human Topoisomerase II Isoforms with Small MoleculesSemantic proximity Read ↗

Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance.Semantic proximity Read ↗

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide.Semantic proximity Read ↗

CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 CellsSemantic proximity Read ↗

Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II alpha.Semantic proximity Read ↗

Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines.Semantic proximity Read ↗

Drug toxicity in E. coli cells expressing human topoisomerase I.Semantic proximity Read ↗

Topoisomerase III-β is required for efficient replication of positive-sense RNA virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.