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A critical role for topoisomerase IIb and DNA double strand breaks in transcription

21 Apr 2016

Abstract excerpt

Recent studies have indicated a novel role for topoisomerase IIb in transcription. Transcription of heat shock genes, serum-induced immediate early genes and nuclear receptor-activated genes, each required DNA double strands generated by topoisomerase IIb. Such strand breaks seemed both necessary and sufficient for transcriptional activation. In addition, such transcription was associated with initiation of the...

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PMID: 27100743
DOI: 10.1080/21541264.2016.1181142

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