Article

Identification of Promoter Elements Responsible for Transcriptional Inhibition of Polo-like Kinase 1 and Topoisomerase IIα Genes by p21WAF1/CIP1/ SDI1

2002-01-01

Abstract excerpt

Induction of p21WAF1/CIP1/SDI1, a physiological mediator of cell cycle arrest, inhibits multiple genes involved in cell division. We have investigated the determinants of p21-mediated inhibition of two of these genes, polo-like kinase 1 (PLK1) and topoisomerase IIa (TOPO IIa). p21 expression from an inducible promoter in human HT1080 cells rapidly decreases cellular levels of PLK1 and TOPO IIa RNA without decreasi...

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Literature Corpus work: ff99087b-649f-5864-aa82-b896e802b69c
DOI: 10.4161/cc.1.1.101

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