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Article

Characterization of promoter elements involved in the down-regulation of topoisomerase IIalpha expression in a drug-resistant cell line.

Gene - 10 Nov 2004

Saxena Deepa, Yiu Gary K, Ni Xiaoyan, Huang Kuan-Chun, Mantovani Roberto, Jacquemin-Sablon Alain G, Ng Shu-Wing

Abstract excerpt

Reduced expression of topoisomerase II is one of the mechanisms observed in cell lines and clinical samples that are resistant to topoisomerase II-targeting agents. The Chinese hamster lung cell line DC-3F/9-OH-E made resistant to 9-OH ellipticine and cross-resistant to other topoisomerase II inhibitors has previously been shown to express lower level of topoisomerase IIalpha isoform, than the parental DC-3F cell...

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Identifiers

PMID: 15527974
DOI: 10.1016/j.gene.2004.07.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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