Article
Domains of human topoisomerase I and associated functions.
Progress in nucleic acid research and molecular biology - 1 Jan 1998
Champoux J J
Abstract excerpt
Human topoisomerase I can be divided into four domains based on homology alignments, physical properties, sensitivity to limited proteolysis, and fragment complementation studies. Roughly the first 197 amino acids represent the N-terminal domain that appears to be devoid of secondary structure an...
Topics
- Binding Sites
- Camptothecin
- DNA
- DNA Topoisomerases, Type I
- Drug Resistance
- Enzyme Inhibitors
- Humans
- Mutation
- Peptide Fragments
- Substrate Specificity