Article
Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Fritz E, Elsea S H, Patel P I, Meyn M S
Abstract excerpt
Ataxia-telangiectasia (A-T) is a recessive human disease characterized by radiation sensitivity, genetic instability, immunodeficiency, and high cancer risk. We previously used expression cloning to identify CAT4.5, a human cDNA that partially suppresses multiple aspects of the A-T phenotype upon transfection into cultured cells. Sequencing CAT4.5 revealed a 1.1-kb intronic fragment followed by a related ORF of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.