Article
Cell cycle-coupled variation in topoisomerase IIalpha mRNA is regulated by the 3'-untranslated region. Possible role of redox-sensitive protein binding in mRNA accumulation.
The Journal of biological chemistry - 8 Dec 2000
Goswami P C, Sheren J, Albee L D, Parsian A, Sim J E, Ridnour L A, Higashikubo R, Gius D, Hunt C R, Spitz D R
Abstract excerpt
Mammalian topoisomerase IIalpha (Topo II) is a highly regulated enzyme essential for many cellular processes including the G(2) cell cycle checkpoint. Because Topo II gene expression is regulated posttranscriptionally during the cell cycle, we investigated the possible role of the 3'-untranslated region (3'-UTR) in controlling Topo II mRNA accumulation. Reporter assays in stably transfected cells demonstrated...
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