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Article

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.

Nature - 27 Mar 1997

Rodriguez-Esteban C, Schwabe J W, De La Peña J, Foys B, Eshelman B, Izpisúa Belmonte J C

Abstract excerpt

Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral limb axis. Radical fringe is expressed in the dorsal ectoderm before the ridge appears, and is repressed by Engrailed-1, which is expressed in the ventral ectoderm. Misexpression of these genes indicates that a ridge is formed wherever there is a boundary...

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Identifiers

PMID: 9121551
DOI: 10.1038/386360a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.PMID 9121551Read ↗

Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.Semantic proximity Read ↗

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.Semantic proximity Read ↗

The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.Semantic proximity Read ↗

Multi-species atlas resolves an axolotl limb development and regeneration paradoxSemantic proximity Read ↗

Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm.Semantic proximity Read ↗

Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo.Semantic proximity Read ↗

The apical ectodermal ridge is a timer for generating distal limb progenitors.Semantic proximity Read ↗

The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila.Semantic proximity Read ↗

fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.Semantic proximity Read ↗

Proboscipedia represses distal signaling in the embryonic gnathal limb fields of Tribolium castaneum.Semantic proximity Read ↗

Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis.Semantic proximity Read ↗

Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.Semantic proximity Read ↗

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