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Article

The apical ectodermal ridge is a timer for generating distal limb progenitors.

Development (Cambridge, England) - 1 Apr 2008

Lu Pengfei, Yu Ying, Perdue Yasmine, Werb Zena

Abstract excerpt

The apical ectodermal ridge (AER) is a transient embryonic structure essential for the induction, patterning and outgrowth of the vertebrate limb. However, the mechanism of AER function in limb skeletal patterning has remained unclear. In this study, we genetically ablated the AER by conditionally removing FGFR2 function and found that distal limb development failed in mutant mice. We showed that FGFR2 promotes...

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Identifiers

PMID: 18359901
DOI: 10.1242/dev.018945
PMCID: PMC2574509

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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