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Article

Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos.

Development (Cambridge, England) - 1 Oct 2004

Kawakami Yasuhiko, Esteban Concepción Rodríguez, Matsui Takaaki, Rodríguez-León Joaquín, Kato Shigeaki, Izpisúa Belmonte Juan Carlos

Abstract excerpt

Initiation and maintenance of signaling centers is a key issue during embryonic development. The apical ectodermal ridge, a specialized epithelial structure and source of Fgf8, is a pivotal signaling center for limb outgrowth. We show that two closely related buttonhead-like zinc-finger transcription factors, Sp8 and Sp9, are expressed in the AER, and regulate Fgf8 expression and limb outgrowth. Embryological and...

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PMID: 15358670
DOI: 10.1242/dev.01331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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