The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

doi:10.1101/gad.5.12b.2363

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Article

The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

Genes & development - 1 Dec 1991

Robert B, Lyons G, Simandl B K, Kuroiwa A, Buckingham M

Abstract excerpt

We show that expression of the two related chicken homeo box genes, Hox-7 and Hox-8, which is widespread in the lateral mesoderm at early stages, becomes restricted to the mesoderm underlying the apical ectodermal ridge as limbs develop. Expression in the limb bud mesoderm is not maintained in th...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chick Embryo
Choristoma
Ectoderm
Extremities
Gene Expression Regulation
Genes, Homeobox
Limb Deformities, Congenital
Molecular Sequence Data
Mutation
Quail

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