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Article

The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.

Genes & development - 1 Dec 1991

Robert B, Lyons G, Simandl B K, Kuroiwa A, Buckingham M

Abstract excerpt

We show that expression of the two related chicken homeo box genes, Hox-7 and Hox-8, which is widespread in the lateral mesoderm at early stages, becomes restricted to the mesoderm underlying the apical ectodermal ridge as limbs develop. Expression in the limb bud mesoderm is not maintained in the limbless mutant, which does not form an apical ridge. The mutant can be rescued by grafting normal ectoderm to the...

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Identifiers

PMID: 1684333
DOI: 10.1101/gad.5.12b.2363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in developing chick limb buds.PMID 1684333Read ↗

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