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Article

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.

Nature genetics - 1 Jul 1997

Cohen B, Bashirullah A, Dagnino L, Campbell C, Fisher W W, Leow C C, Whiting E, Ryan D, Zinyk D, Boulianne G, Hui C C, Gallie B, Phillips R A, Lipshitz H D, Egan S E

Abstract excerpt

In both vertebrate and invertebrate development, cells are often programmed to adopt fates distinct from their neighbors. Genetic analyses in Drosophila melanogaster have highlighted the importance of cell surface and secreted proteins in these cell fate decisions. Homologues of these proteins ha...

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Identifiers

PMID: 9207795
DOI: 10.1038/ng0797-283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9207795-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila.PMID 9207795Read ↗

Fringe forms a complex with Notch.Semantic proximity Read ↗

fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.Semantic proximity Read ↗

Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation.Semantic proximity Read ↗

Defects in somite formation in lunatic fringe-deficient mice.Semantic proximity Read ↗

Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila.Semantic proximity Read ↗

Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine.Semantic proximity Read ↗

Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth.Semantic proximity Read ↗

Secreted Frizzled-related proteins can regulate metanephric developmentSemantic proximity Read ↗

Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events.Semantic proximity Read ↗

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.Semantic proximity Read ↗

Expression of Radical fringe in limb-bud ectoderm regulates apical ectodermal ridge formation.Semantic proximity Read ↗

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.Semantic proximity Read ↗

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