The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.

doi:10.1002/hep.24280

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Article

The stable repression of mesenchymal program is required for hepatocyte identity: a novel role for hepatocyte nuclear factor 4α.

Hepatology (Baltimore, Md.) - 1 Jun 2011

Santangelo Laura, Marchetti Alessandra, Cicchini Carla, Conigliaro Alice, Conti Beatrice, Mancone Carmine, Bonzo Jessica A, Gonzalez Frank J, Alonzi Tonino, Amicone Laura, Tripodi Marco

Abstract excerpt

UNLABELLED: The concept that cellular terminal differentiation is stably maintained once development is complete has been questioned by numerous observations showing that differentiated epithelium may undergo an epithelial-to-mesenchymal transition (EMT) program. EMT and the reverse process, mesenchymal-to-epithelial transition (MET), are typical events of development, tissue repair, and tumor progression. In...

Topics

Animals
Carcinoma, Hepatocellular
Cell Differentiation
Cell Line, Tumor
Epithelial Cells
Hepatocyte Nuclear Factor 1-alpha
Hepatocyte Nuclear Factor 4
Hepatocytes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Mesoderm

Mice

Mice, Knockout

Models, Animal

Phenotype

Snail Family Transcription Factors

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21384409
DOI: 10.1002/hep.24280
PMCID: PMC6624426

Genes

MET
HMGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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