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Article

Evolutionary dynamics of the human immunoglobulin κ locus and the germline repertoire of the Vκ genes

1 Apr 2001

Abstract excerpt

We have determined the entire nucleotide sequence of the human immunoglobulin kappa locus, comprising a total of 1,010,706 nucleotides. The 76 Vkappa genes found by a hybridization-based approach and their classification in 7 families were confirmed. A Vkappa orphon located near the locus was also sequenced. In addition, we identified 55 novel Vkappa relics and truncated pseudogenes, which establish 5 new...

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PMID: 11298326
DOI: 10.1002/1521-4141(200104)31:4<1017::aid-immu1017>3.0.co;2-3

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Source receipt: pubmed, retrieved 7 Sept 2026.

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