Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.

15 Aug 1998

Abstract excerpt

To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined. No differences in the Vkappa and Jkappa gene usage in the nonproductive gene repertoire of this SLE patient were noted compared with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Monoclonal and Polyclonal Antibodies Research
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9710436
DOI: 10.1172/jci3113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.PMID 9710436Read ↗

Enhanced mutational activity of Vkappa gene rearrangements in systemic lupus erythematosus.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus.Semantic proximity Read ↗

Editing disease-associated autoantibodies.Semantic proximity Read ↗

B cell receptor editing in tolerance and autoimmunitySemantic proximity Read ↗

Targeting and subsequent selection of somatic hypermutations in the human V kappa repertoire.Semantic proximity Read ↗

Molecular basis of immunoglobulin variable region gene usage in systemic autoimmunitySemantic proximity Read ↗

Genetic dissection of lupus pathogenesis: Sle3/5 impacts IgH CDR3 sequences, somatic mutations, and receptor editing.Semantic proximity Read ↗

Receptor editing in peripheral B cell tolerance.Semantic proximity Read ↗

RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.Semantic proximity Read ↗

The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR); frequent occurrence of features often assigned to autoimmunity.Semantic proximity Read ↗

Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.