Article
Somatic hypermutation and the three R's: repair, replication and recombination.
Mutation research - 1 Mar 1999
Harris R S, Kong Q, Maizels N
Abstract excerpt
Somatic hypermutation introduces single base changes into the rearranged variable (V) regions of antigen activated B cells at a rate of approximately 1 mutation per kilobase per generation. This is nearly a million-fold higher than the typical mutation rate in a mammalian somatic cell. Rampant mutation at this level could have a devastating effect, but somatic hypermutation is accurately targeted and tightly...
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