Article
Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene.
Science (New York, N.Y.) - 9 Sept 1994
Xu B, Selsing E
Abstract excerpt
The role of gene conversion in murine immunoglobulin gene diversification is unclear. An antibody gene construct designed to provide the homologous donor and acceptor sequences required for conversion mechanisms was produced and used to generate transgenic mice. When these transgenic mice were im...
Topics
- Animals
- Antibody Diversity
- B-Lymphocytes
- Base Sequence
- Cell Differentiation
- Gene Conversion
- Genes, Immunoglobulin
- Hybridomas
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation